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An Integrative Approach to Assess X-Chromosome Inactivation Using Allele-Specific Expression with Applications to Epithelial Ovarian Cancer
X-chromosome inactivation (XCI) epigenetically silences transcription of an X chromosome in females; patterns of XCI are thought to be aberrant in women’s cancers, but are understudied due to statistical challenges. We develop a two-stage statistical framework to assess skewed XCI and evaluate gene-...
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| Publicado no: | Genet Epidemiol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5726546/ https://ncbi.nlm.nih.gov/pubmed/29119601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.22091 |
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