Fibroblast Growth Factor 21 Improves Hepatic Insulin Sensitivity by Inhibiting Mammalian Target of Rapamycin Complex 1 in Mice

Among the 22 fibroblast growth factors (FGFs), FGF21 has now emerged as a key metabolic regulator. However, the mechanism whereby FGF21 mediates its metabolic actions per se remains largely unknown. Here, we show that FGF21 represses mammalian target of rapamycin complex 1 (mTORC1) and improves insu...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Gong, Qi, Hu, Zhimin, Zhang, Feifei, Cui, Aoyuan, Chen, Xin, Jiang, Haoyang, Gao, Jing, Chen, Xuqing, Han, Yamei, Liang, Qingning, Ye, Dewei, Shi, Lei, Chin, Y. Eugene, Wang, Yu, Xiao, Hui, Guo, Feifan, Liu, Yong, Zang, Mengwei, Xu, Aimin, Li, Yu
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5726522/
https://ncbi.nlm.nih.gov/pubmed/26926384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28523
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