A simple and accurate rule-based modeling framework for simulation of autocrine/paracrine stimulation of glioblastoma cell motility and proliferation by L1CAM in 2-D culture

BACKGROUND: Glioblastoma multiforme (GBM) is a devastating brain cancer for which there is no known cure. Its malignancy is due to rapid cell division along with high motility and invasiveness of cells into the brain tissue. Simple 2-dimensional laboratory assays (e.g., a scratch assay) commonly are...

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Publicat a:BMC Syst Biol
Autors principals: Caccavale, Justin, Fiumara, David, Stapf, Michael, Sweitzer, Liedeke, Anderson, Hannah J., Gorky, Jonathan, Dhurjati, Prasad, Galileo, Deni S.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Methodology Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725844/
https://ncbi.nlm.nih.gov/pubmed/29228953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12918-017-0516-z
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