Silica inhalation altered telomere length and gene expression of telomere regulatory proteins in lung tissue of rats

Exposure to silica can cause lung fibrosis and cancer. Identification of molecular targets is important for the intervention and/or prevention of silica-induced lung diseases. Telomeres consist of tandem repeats of DNA sequences at the end of chromosomes, preventing chromosomal fusion and degradatio...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Shoeb, Mohammad, Joseph, Pius, Kodali, Vamsi, Mustafa, Gul, Farris, Breanne Y., Umbright, Christina, Roberts, Jenny R., Erdely, Aaron, Antonini, James M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725592/
https://ncbi.nlm.nih.gov/pubmed/29230030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17645-y
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