CpG-oligodeoxynucleotides developed for grouper toll-like receptor (TLR) 21s effectively activate mouse and human TLR9s mediated immune responses

Synthetic phosphorothiolate-modified CpG-oligodeoxynucleotides (CpG-ODNs) are potent immune stimuli. Toll-like receptor (TLR) 9 and TLR21 are their cellular receptors in different species. The structural requirements for CpG-ODN to strongly activate TLR9 have been relatively well studied, but studie...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Yeh, Da-Wei, Lai, Chao-Yang, Liu, Yi-Ling, Lu, Chih-Hao, Tseng, Ping-Hui, Yuh, Chiou-Hwa, Yu, Guann-Yi, Liu, Shih-Jen, Leng, Chih-Hsiang, Chuang, Tsung-Hsien
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725558/
https://ncbi.nlm.nih.gov/pubmed/29229937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17609-2
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