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Opioids and the Blood-Brain Barrier: A Dynamic Interaction with Consequences on Drug Disposition in Brain
BACKGROUND: Opioids are widely used in pain management, acting via opioid receptors and/or Toll-like receptors (TLR) present at the central nervous system (CNS). At the blood-brain barrier (BBB), several influx and efflux transporters, such as the ATP-binding cassette (ABC) P-glycoprotein (P-gp, ABC...
Enregistré dans:
| Publié dans: | Curr Neuropharmacol |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Bentham Science Publishers
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5725546/ https://ncbi.nlm.nih.gov/pubmed/28474563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1570159X15666170504095823 |
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