Post-transcriptional 3´-UTR cleavage of mRNA transcripts generates thousands of stable uncapped autonomous RNA fragments

The majority of mammalian genes contain one or more alternative polyadenylation sites. Choice of polyadenylation sites was suggested as one of the underlying mechanisms for generating longer/shorter transcript isoforms. Here, we demonstrate that mature mRNA transcripts can undergo additional cleavag...

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Publicado no:Nat Commun
Main Authors: Malka, Yuval, Steiman-Shimony, Avital, Rosenthal, Eran, Argaman, Liron, Cohen-Daniel, Leonor, Arbib, Eliran, Margalit, Hanah, Kaplan, Tommy, Berger, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725528/
https://ncbi.nlm.nih.gov/pubmed/29229900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02099-7
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