Vaccination with a codon-optimized A27L-containing plasmid decreases virus replication and dissemination after vaccinia virus challenge

Smallpox is a disease caused by Variola virus (VARV). Although eradicated by WHO in 1980, the threat of using VARV on a bioterror attack has increased. The current smallpox vaccine ACAM2000, which consists of live vaccinia virus (VACV), causes complications in individuals with a compromised immune s...

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Bibliographische Detailangaben
Veröffentlicht in:Vaccine
Hauptverfasser: Martínez, Osmarie, Cruz, Ariana Bravo, Santos, Saritza, Ramírez, Maite, Miranda, Eric, Shisler, Joanna, Otero, Miguel
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724039/
https://ncbi.nlm.nih.gov/pubmed/28629922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2017.05.091
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