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A cholesterol-sensing mechanism unfolds
Squalene monooxygenase (SM), which synthesizes a cholesterol precursor, is degraded when cholesterol levels in the endoplasmic reticulum (ER) membrane are high, but the signal for degradation was not known. In this issue of JBC, Brown and co-workers identify an N-terminal domain in SM that interconv...
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| Publicado no: | J Biol Chem |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5723985/ https://ncbi.nlm.nih.gov/pubmed/29222193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.H117.794230 |
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