Targeted elimination of senescent Ras-transformed cells by suppression of MEK/ERK pathway

The Ras-Raf-MEK-ERK pathway plays a central role in tumorigenesis and is a target for anticancer therapy. The successful strategy based on the activation of cell death in Ras-expressing cells is associated with the suppression of kinases involved in Ras pathway. However, activation of cytoprotective...

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Bibliographic Details
Published in:Aging (Albany NY)
Main Authors: Kochetkova, Elena Y., Blinova, Galina I., Bystrova, Olga A., Martynova, Marina G., Pospelov, Valery A., Pospelova, Tatiana V.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2017
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5723691/
https://ncbi.nlm.nih.gov/pubmed/29140794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101325
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