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Delivery Strategies of the CRISPR-Cas9 Gene-Editing System for Therapeutic Applications
The CRISPR-Cas9 genome-editing system is a part of the adaptive immune system in archaea and bacteria to defend against invasive nucleic acids from phages and plasmids. The single guide RNA (sgRNA) of the system recognizes its target sequence in the genome, and the Cas9 nuclease of the system acts a...
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| Pubblicato in: | J Control Release |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5723556/ https://ncbi.nlm.nih.gov/pubmed/28911805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2017.09.012 |
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