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Targeting the ubiquitin-proteasome system for cancer treatment: discovering novel inhibitors from nature and drug repurposing

In the past fifteen years, the proteasome has been validated as an anticancer drug target and 20S proteasome inhibitors (such as bortezomib and carfilzomib) have been approved by the FDA for the treatment of multiple myeloma and some other liquid tumors. However, there are shortcomings of clinical p...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Cancer Metastasis Rev
Main Authors: Soave, Claire L., Guerin, Tracey, Liu, Jinbao, Dou, Q. Ping
פורמט: Artigo
שפה:Inglês
יצא לאור: 2017
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722705/
https://ncbi.nlm.nih.gov/pubmed/29047025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10555-017-9705-x
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