Human Primary Liver Cancer -derived Organoid Cultures for disease modelling and drug screening

Human liver cancer research currently lacks in vitro models that faithfully recapitulate the pathophysiology of the original tumour. We recently described a novel, near-physiological organoid culture system, where primary human healthy liver cells form long-term expanding organoids that retain liver...

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Pubblicato in:Nat Med
Autori principali: Broutier, Laura, Mastrogiovanni, Gianmarco, Verstegen, Monique M.A., Francies, Hayley E., Gavarró, Lena Morrill, Bradshaw, Charles R, Allen, George E, Arnes-Benito, Robert, Sidorova, Olga, Gaspersz, Marcia P., Georgakopoulos, Nikitas, Koo, Bon-Kyoung, Dietmann, Sabine, Davies, Susan E., Praseedom, Raaj K., Lieshout, Ruby, IJzermans, Jan N. M., Wigmore, Stephen J, Saeb-Parsy, Kourosh, Garnett, Mathew J., van der Laan, Luc J.W., Huch, Meritxell
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722201/
https://ncbi.nlm.nih.gov/pubmed/29131160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4438
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