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Development of a strategy and computational application to select candidate protein analogues with reduced HLA binding and immunogenicity
Unwanted immune responses against protein therapeutics can reduce efficacy or lead to adverse reactions. T‐cell responses are key in the development of such responses, and are directed against immunodominant regions within the protein sequence, often associated with binding to several allelic varian...
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| Udgivet i: | Immunology |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5721253/ https://ncbi.nlm.nih.gov/pubmed/28833085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12816 |
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