Photosensitizer (PS)-Cyanine Dye (CD) Conjugates: Impact of the Linkers Joining the PS and CD Moieties and Their Orientation in Tumor-Uptake and Photodynamic Therapy (PDT)

To investigate the impact of linker(s) joining the photosensitizer HPPH [3-(1’-hexyloxy) ethyl-3-devinylpyropheophorbide-a] and the cyanine dye (CD) in tumor-imaging and photodynamic therapy (dual-function agents), a series of HPPH-CD conjugates were synthesized. The modifications were done in an at...

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Veröffentlicht in:Eur J Med Chem
Hauptverfasser: James, Nadine S., Joshi, Penny, Ohulchanskyy, Tymish Y., Chen, Yihui, Tabaczynski, Walter, Durrani, Farukh, Shibata, Masayuki, Pandey, Ravindra K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5720162/
https://ncbi.nlm.nih.gov/pubmed/27543778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2016.06.045
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