Chromosome 9p copy number gains involving PD-L1 are associated with a specific proliferation and immune-modulating gene expression program active across major cancer types

BACKGROUND: Inhibition of the PD-L1/PD-1 immune checkpoint axis represents one of the most promising approaches of immunotherapy for various cancer types. However, immune checkpoint inhibition is successful only in subpopulations of patients emphasizing the need for powerful biomarkers that adequate...

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Publicado en:BMC Med Genomics
Autores principales: Budczies, Jan, Denkert, Carsten, Győrffy, Balázs, Schirmacher, Peter, Stenzinger, Albrecht
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5719741/
https://ncbi.nlm.nih.gov/pubmed/29212506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-017-0308-8
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