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Chromosome 9p copy number gains involving PD-L1 are associated with a specific proliferation and immune-modulating gene expression program active across major cancer types

BACKGROUND: Inhibition of the PD-L1/PD-1 immune checkpoint axis represents one of the most promising approaches of immunotherapy for various cancer types. However, immune checkpoint inhibition is successful only in subpopulations of patients emphasizing the need for powerful biomarkers that adequate...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:BMC Med Genomics
Main Authors: Budczies, Jan, Denkert, Carsten, Győrffy, Balázs, Schirmacher, Peter, Stenzinger, Albrecht
פורמט: Artigo
שפה:Inglês
יצא לאור: BioMed Central 2017
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5719741/
https://ncbi.nlm.nih.gov/pubmed/29212506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-017-0308-8
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