Chromosome 9p copy number gains involving PD-L1 are associated with a specific proliferation and immune-modulating gene expression program active across major cancer types

BACKGROUND: Inhibition of the PD-L1/PD-1 immune checkpoint axis represents one of the most promising approaches of immunotherapy for various cancer types. However, immune checkpoint inhibition is successful only in subpopulations of patients emphasizing the need for powerful biomarkers that adequate...

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Bibliografiska uppgifter
I publikationen:BMC Med Genomics
Huvudupphovsmän: Budczies, Jan, Denkert, Carsten, Győrffy, Balázs, Schirmacher, Peter, Stenzinger, Albrecht
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2017
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5719741/
https://ncbi.nlm.nih.gov/pubmed/29212506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-017-0308-8
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