Local Production of Activated Factor X in Atherosclerotic Plaque Induced Vascular Smooth Muscle Cell Senescence

Our previous study demonstrated that coagulation factor Xa (FXa) induced endothelial cell senescence, resulting in inflammation and impaired angiogenesis. This mechanism is dictated through protease-activated receptors, PARs, insulin-like growth factor-binding protein 5 (IGFBP-5), and p53. Activatio...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Sanada, Fumihiro, Muratsu, Jun, Otsu, Rei, Shimizu, Hideo, Koibuchi, Nobutaka, Uchida, Kazutaka, Taniyama, Yoshiaki, Yoshimura, Shinichi, Rakugi, Hiromi, Morishita, Ryuichi
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5719421/
https://ncbi.nlm.nih.gov/pubmed/29215061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17508-6
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