Transplantation of a quaternary structure neutralizing antibody epitope from dengue virus serotype 3 into serotype 4

Dengue vaccine trials have revealed deficits in our understanding of the mechanisms of protective immunity, demonstrating a need to measure epitope-specific antibody responses against each DENV serotype. HmAb 5J7 binds to a complex, 3-monomer spanning quaternary epitope in the DENV3 envelope (E) pro...

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Vydáno v:Sci Rep
Hlavní autoři: Widman, Douglas G., Young, Ellen, Nivarthi, Usha, Swanstrom, Jesica A., Royal, Scott R., Yount, Boyd L., Debbink, Kari, Begley, Matthew, Marcet, Stephanie, Durbin, Anna, de Silva, Aravinda M., Messer, William B., Baric, Ralph S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5719398/
https://ncbi.nlm.nih.gov/pubmed/29215033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17355-5
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