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Toll-like Receptor Activation Induces Degeneration of Human Intervertebral Discs

Toll-like receptors (TLR) are activated by endogenous alarmins such as fragmented extracellular matrix compounds found in the degenerating disc. TLRs regulate cytokine, neurotrophin, and protease expression in human disc cells in vitro, and thus control key factors in disc degeneration. However, whe...

詳細記述

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書誌詳細
出版年:Sci Rep
主要な著者: Krock, Emerson, Rosenzweig, Derek H., Currie, J. Brooke, Bisson, Daniel G., Ouellet, Jean A., Haglund, Lisbet
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5719358/
https://ncbi.nlm.nih.gov/pubmed/29215065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17472-1
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