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High mechanical strain of primary intervertebral disc cells promotes secretion of inflammatory factors associated with disc degeneration and pain

INTRODUCTION: Excessive mechanical loading of intervertebral discs (IVDs) is thought to alter matrix properties and influence disc cell metabolism, contributing to degenerative disc disease and development of discogenic pain. However, little is known about how mechanical strain induces these changes...

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Detalhes bibliográficos
Main Authors: Gawri, Rahul, Rosenzweig, Derek H, Krock, Emerson, Ouellet, Jean A, Stone, Laura S, Quinn, Thomas M, Haglund, Lisbet
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979109/
https://ncbi.nlm.nih.gov/pubmed/24457003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4449
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