Omega-3 PUFA ameliorates hyperhomocysteinemia-induced hepatic steatosis in mice by inhibiting hepatic ceramide synthesis

Hyperhomocysteinemia (HHcy) is a key risk factor in hepatic steatosis. In this study, we applied a metabolomic approach to investigate the changes in the metabolite profile due to HHcy-induced hepatic steatosis and the effects of omega-3 PUFA (polyunsaturated fatty acid) supplementation in mice. HHc...

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Bibliographic Details
Published in:Acta Pharmacol Sin
Main Authors: Dong, Yong-qiang, Zhang, Xing-zhong, Sun, Lu-lu, Zhang, Song-yang, Liu, Bo, Liu, Hui-ying, Wang, Xian, Jiang, Chang-tao
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5719150/
https://ncbi.nlm.nih.gov/pubmed/28933423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.127
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