The conserved ancient role of chordate PIAS as a multilevel repressor of the NF-κB pathway

In vertebrates, PIAS genes encode versatile cellular regulators, with functions extremely complex and redundant. Here we try to understand their functions from an evolutionary perspective. we evaluate the sequences, expression and molecular functions of amphioxus PIAS genes and compare them with the...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Wang, Ruihua, Huang, Shengfeng, Fu, Xianan, Huang, Guangrui, Yan, Xinyu, Yue, Zirui, Chen, Shangwu, Li, Yingqiu, Xu, Anlong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5719053/
https://ncbi.nlm.nih.gov/pubmed/29213053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16624-7
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