The conserved ancient role of chordate PIAS as a multilevel repressor of the NF-κB pathway

In vertebrates, PIAS genes encode versatile cellular regulators, with functions extremely complex and redundant. Here we try to understand their functions from an evolutionary perspective. we evaluate the sequences, expression and molecular functions of amphioxus PIAS genes and compare them with the...

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Udgivet i:Sci Rep
Main Authors: Wang, Ruihua, Huang, Shengfeng, Fu, Xianan, Huang, Guangrui, Yan, Xinyu, Yue, Zirui, Chen, Shangwu, Li, Yingqiu, Xu, Anlong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5719053/
https://ncbi.nlm.nih.gov/pubmed/29213053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16624-7
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