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Abrogating mitochondrial dynamics in mouse hearts accelerates mitochondrial senescence

Mitochondrial fusion and fission are critical to heart health; genetically interrupting either is rapidly lethal. To understand whether it is loss of, or the imbalance between, fusion and fission that underlies observed cardiac phenotypes, we engineered mice in which Mfn-mediated fusion and Drp1-med...

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Bibliografske podrobnosti
izdano v:Cell Metab
Main Authors: Song, Moshi, Franco, Antonietta, Fleischer, Julie A, Zhang, Lihong, Dorn, Gerald W
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5718956/
https://ncbi.nlm.nih.gov/pubmed/29107503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.09.023
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