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Abrogating mitochondrial dynamics in mouse hearts accelerates mitochondrial senescence
Mitochondrial fusion and fission are critical to heart health; genetically interrupting either is rapidly lethal. To understand whether it is loss of, or the imbalance between, fusion and fission that underlies observed cardiac phenotypes, we engineered mice in which Mfn-mediated fusion and Drp1-med...
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| Publicado no: | Cell Metab |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5718956/ https://ncbi.nlm.nih.gov/pubmed/29107503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.09.023 |
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