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Abrogating mitochondrial dynamics in mouse hearts accelerates mitochondrial senescence

Mitochondrial fusion and fission are critical to heart health; genetically interrupting either is rapidly lethal. To understand whether it is loss of, or the imbalance between, fusion and fission that underlies observed cardiac phenotypes, we engineered mice in which Mfn-mediated fusion and Drp1-med...

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Foilsithe in:Cell Metab
Main Authors: Song, Moshi, Franco, Antonietta, Fleischer, Julie A, Zhang, Lihong, Dorn, Gerald W
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5718956/
https://ncbi.nlm.nih.gov/pubmed/29107503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.09.023
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