Persistence of DNA adducts, hypermutation and acquisition of cellular resistance to alkylating agents in glioblastoma

Glioblastoma is a lethal form of brain tumour usually treated by surgical resection followed by radiotherapy and an alkylating chemotherapeutic agent. Key to the success of this multimodal approach is maintaining apoptotic sensitivity of tumour cells to the alkylating agent. This initial treatment l...

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Gepubliceerd in:Cancer Biol Ther
Hoofdauteurs: Head, R. J., Fay, M. F., Cosgrove, L., Y. C. Fung, K., Rundle-Thiele, D., Martin, J. H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2017
Onderwerpen:
Review
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5718815/
https://ncbi.nlm.nih.gov/pubmed/29020502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2017.1385680
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