Persistence of DNA adducts, hypermutation and acquisition of cellular resistance to alkylating agents in glioblastoma

Glioblastoma is a lethal form of brain tumour usually treated by surgical resection followed by radiotherapy and an alkylating chemotherapeutic agent. Key to the success of this multimodal approach is maintaining apoptotic sensitivity of tumour cells to the alkylating agent. This initial treatment l...

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Bibliografiske detaljer
Udgivet i:Cancer Biol Ther
Main Authors: Head, R. J., Fay, M. F., Cosgrove, L., Y. C. Fung, K., Rundle-Thiele, D., Martin, J. H.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2017
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5718815/
https://ncbi.nlm.nih.gov/pubmed/29020502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2017.1385680
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