Epitope mapping of Ebola virus dominant and subdominant glycoprotein epitopes facilitates construction of an epitope-based DNA vaccine able to focus the antibody response in mice

We performed epitope mapping studies on the major surface glycoprotein (GP) of Ebola virus (EBOV) using Chemically Linked Peptides on Scaffolds (CLIPS), which form linear and potential conformational epitopes. This method identified monoclonal antibody epitopes and predicted additional epitopes reco...

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Bibliographische Detailangaben
Veröffentlicht in:Hum Vaccin Immunother
Hauptverfasser: Mitchell, Daniel A. J., Dupuy, Lesley C., Sanchez-Lockhart, Mariano, Palacios, Gustavo, Back, Jaap W., Shimanovskaya, Katya, Chaudhury, Sidhartha, Ripoll, Daniel R., Wallqvist, Anders, Schmaljohn, Connie S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2017
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5718802/
https://ncbi.nlm.nih.gov/pubmed/28699812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21645515.2017.1347740
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