Epitope mapping of Ebola virus dominant and subdominant glycoprotein epitopes facilitates construction of an epitope-based DNA vaccine able to focus the antibody response in mice

We performed epitope mapping studies on the major surface glycoprotein (GP) of Ebola virus (EBOV) using Chemically Linked Peptides on Scaffolds (CLIPS), which form linear and potential conformational epitopes. This method identified monoclonal antibody epitopes and predicted additional epitopes reco...

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Detalhes bibliográficos
Publicado no:Hum Vaccin Immunother
Main Authors: Mitchell, Daniel A. J., Dupuy, Lesley C., Sanchez-Lockhart, Mariano, Palacios, Gustavo, Back, Jaap W., Shimanovskaya, Katya, Chaudhury, Sidhartha, Ripoll, Daniel R., Wallqvist, Anders, Schmaljohn, Connie S.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5718802/
https://ncbi.nlm.nih.gov/pubmed/28699812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21645515.2017.1347740
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