Interleukin-36γ and IL-36 receptor signaling mediate impaired host immunity and lung injury in cytotoxic Pseudomonas aeruginosa pulmonary infection: Role of prostaglandin E2

Pseudomonas aeruginosa is a Gram-negative pathogen that can lead to severe infection associated with lung injury and high mortality. The interleukin (IL)-36 cytokines (IL-36α, IL-36β and IL-36γ) are newly described IL-1 like family cytokines that promote inflammatory response via binding to the IL-3...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Aoyagi, Tetsuji, Newstead, Michael W., Zeng, Xianying, Nanjo, Yuta, Peters-Golden, Marc, Kaku, Mitsuo, Standiford, Theodore J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5718565/
https://ncbi.nlm.nih.gov/pubmed/29166668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006737
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