Short-term succinic acid treatment mitigates cerebellar mitochondrial OXPHOS dysfunction, neurodegeneration and ataxia in a Purkinje-specific spinocerebellar ataxia type 1 (SCA1) mouse model

Mitochondrial dysfunction plays a significant role in neurodegenerative disease including ataxias and other movement disorders, particularly those marked by progressive degeneration in the cerebellum. In this study, we investigate the role of mitochondrial oxidative phosphorylation (OXPHOS) deficits...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:PLoS One
Main Authors: Ferro, Austin, Carbone, Emily, Zhang, Jenny, Marzouk, Evan, Villegas, Monica, Siegel, Asher, Nguyen, Donna, Possidente, Thomas, Hartman, Jessilyn, Polley, Kailen, Ingram, Melissa A., Berry, Georgia, Reynolds, Thomas H., Possidente, Bernard, Frederick, Kimberley, Ives, Stephen, Lagalwar, Sarita
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2017
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5718515/
https://ncbi.nlm.nih.gov/pubmed/29211771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0188425
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