Reverse electron transfer results in a loss of flavin from mitochondrial complex I: Potential mechanism for brain ischemia reperfusion injury

Ischemic stroke is one of the most prevalent sources of disability in the world. The major brain tissue damage takes place upon the reperfusion of ischemic tissue. Energy failure due to alterations in mitochondrial metabolism and elevated production of reactive oxygen species (ROS) is one of the mai...

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Bibliographic Details
Published in:J Cereb Blood Flow Metab
Main Authors: Stepanova, Anna, Kahl, Anja, Konrad, Csaba, Ten, Vadim, Starkov, Anatoly S, Galkin, Alexander
Format: Artigo
Language:Inglês
Published: SAGE Publications 2017
Subjects:
Rapid Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5718331/
https://ncbi.nlm.nih.gov/pubmed/28914132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X17730242
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