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When and how should multiple imputation be used for handling missing data in randomised clinical trials – a practical guide with flowcharts

BACKGROUND: Missing data may seriously compromise inferences from randomised clinical trials, especially if missing data are not handled appropriately. The potential bias due to missing data depends on the mechanism causing the data to be missing, and the analytical methods applied to amend the miss...

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Detalhes bibliográficos
Publicado no:BMC Med Res Methodol
Main Authors: Jakobsen, Janus Christian, Gluud, Christian, Wetterslev, Jørn, Winkel, Per
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5717805/
https://ncbi.nlm.nih.gov/pubmed/29207961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-017-0442-1
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