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Heat shock proteins and cancer: intracellular chaperones or extracellular signalling ligands?
Heat shock proteins (HSPs) are found at elevated concentrations in tumour cells, and this increase reflects the proteotoxic stress experienced by the cells due to expanding levels of the mutated oncoproteins that drive tumorigenesis. The protection of oncogenic proteins by HSPs offers a window of vu...
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| 發表在: | Philos Trans R Soc Lond B Biol Sci |
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| 主要作者: | |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Royal Society
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5717524/ https://ncbi.nlm.nih.gov/pubmed/29203709 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2016.0524 |
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