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Autophagy inhibition sensitizes LY3023414-induced anti-glioma cell activity in vitro and in vivo
PI3K-AKT-mTOR signaling is a valuable treatment target for human glioma. LY3023414 is a novel, highly-potent and pan PI3K-AKT-mTOR inhibitor. Here, we show that LY3023414 efficiently inhibited survival and proliferation of primary and established human glioma cells. Meanwhile, apoptosis activation w...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5716781/ https://ncbi.nlm.nih.gov/pubmed/29228741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22147 |
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