Autophagy inhibition sensitizes LY3023414-induced anti-glioma cell activity in vitro and in vivo

PI3K-AKT-mTOR signaling is a valuable treatment target for human glioma. LY3023414 is a novel, highly-potent and pan PI3K-AKT-mTOR inhibitor. Here, we show that LY3023414 efficiently inhibited survival and proliferation of primary and established human glioma cells. Meanwhile, apoptosis activation w...

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Foilsithe in:Oncotarget
Main Authors: Zheng, Lan, Li, Huanyin, Mo, Yanqing, Qi, Gong, Liu, Bin, Zhao, Jing
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2017
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716781/
https://ncbi.nlm.nih.gov/pubmed/29228741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22147
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