The EZH2 inhibitor GSK343 suppresses cancer stem-like phenotypes and reverses mesenchymal transition in glioma cells

Enhancer of zeste homolog 2 (EZH2) is the catalytic unit of polycomb repressive complex 2 (PRC2) which epigenetically silences many genes involved in tumor-suppressive mechanisms via the trimethylation of lysine 27 of histone H3 (H3K27me3). We recently found that overexpression of EZH2 was associate...

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Опубликовано в: :Oncotarget
Главные авторы: Yu, Tianfu, Wang, Yingyi, Hu, Qi, Wu, WeiNing, Wu, Youzhi, Wei, Wenjin, Han, Dongfeng, You, Yongping, Lin, Ning, Liu, Ning
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2017
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Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716734/
https://ncbi.nlm.nih.gov/pubmed/29228694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21311
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