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The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets
The hexameric AAA ATPase Vps4 drives membrane fission by remodeling and disassembling ESCRT-III filaments. Building upon our earlier 4.3 Å resolution cryo-EM structure (Monroe et al., 2017), we now report a 3.2 Å structure of Vps4 bound to an ESCRT-III peptide substrate. The new structure reveals th...
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| Vydáno v: | eLife |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
eLife Sciences Publications, Ltd
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5716660/ https://ncbi.nlm.nih.gov/pubmed/29165244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31324 |
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