Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase

Many important cellular membrane fission reactions are driven by ESCRT pathways, which culminate in disassembly of ESCRT-III polymers by the AAA ATPase Vps4. We report a 4.3 Å resolution cryo-EM structure of the active Vps4 hexamer with its cofactor Vta1, ADP·BeF(x), and an ESCRT-III substrate pepti...

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Bibliographic Details
Published in:eLife
Main Authors: Monroe, Nicole, Han, Han, Shen, Peter S, Sundquist, Wesley I, Hill, Christopher P
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2017
Subjects:
Biochemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413351/
https://ncbi.nlm.nih.gov/pubmed/28379137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24487
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