UNC-16/JIP3 regulates early events in synaptic vesicle protein trafficking via LRK-1/LRRK2 and AP complexes

JIP3/UNC-16/dSYD is a MAPK-scaffolding protein with roles in protein trafficking. We show that it is present on the Golgi and is necessary for the polarized distribution of synaptic vesicle proteins (SVPs) and dendritic proteins in neurons. UNC-16 excludes Golgi enzymes from SVP transport carriers a...

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Udgivet i:PLoS Genet
Main Authors: Choudhary, Bikash, Kamak, Madhushree, Ratnakaran, Neena, Kumar, Jitendra, Awasthi, Anjali, Li, Chun, Nguyen, Ken, Matsumoto, Kunihiro, Hisamoto, Naoki, Koushika, Sandhya P.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716593/
https://ncbi.nlm.nih.gov/pubmed/29145394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007100
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