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Basic domain of telomere guardian TRF2 reduces D-loop unwinding whereas Rap1 restores it
Telomeric repeat binding factor 2 (TRF2) folds human telomeres into loops to prevent unwanted DNA repair and chromosome end-joining. The N-terminal basic domain of TRF2 (B-domain) protects the telomeric displacement loop (D-loop) from cleavage by endonucleases. Repressor activator protein 1 (Rap1) b...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5716094/ https://ncbi.nlm.nih.gov/pubmed/28981702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx812 |
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