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T cell receptor sequencing of early-stage breast cancer tumors identifies altered clonal structure of the T cell repertoire

Tumor-infiltrating T cells play an important role in many cancers, and can improve prognosis and yield therapeutic targets. We characterized T cells infiltrating both breast cancer tumors and the surrounding normal breast tissue to identify T cells specific to each, as well as their abundance in per...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Beausang, John F., Wheeler, Amanda J., Chan, Natalie H., Hanft, Violet R., Dirbas, Frederick M., Jeffrey, Stefanie S., Quake, Stephen R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5715779/
https://ncbi.nlm.nih.gov/pubmed/29138313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1713863114
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