RSK2 phosphorylates T-bet to attenuate colon cancer metastasis and growth

Metastasis is a major cause of cancer-related deaths. Approximately 80% of patients with colorectal cancer develop liver metastasis and 20% develop lung metastasis. We found that at different stages of colon cancer, IFNγ secretion from peripheral blood mononuclear cells was decreased compared with h...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Yao, Ke, Peng, Cong, Zhang, Yuwen, Zykova, Tatyana A., Lee, Mee-Hyun, Lee, Sung-Young, Rao, Enyu, Chen, Hanyong, Ryu, Joohyun, Wang, Lei, Zhang, Yi, Gao, Ge, He, Wei, Ma, Wei-Ya, Liu, Kangdong, Bode, Ann M., Dong, Ziming, Li, Bing, Dong, Zigang
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5715759/
https://ncbi.nlm.nih.gov/pubmed/29133416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710756114
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