Eriodictyol Inhibits RSK2-ATF1 Signaling and Suppresses EGF-induced Neoplastic Cell Transformation

RSK2 is a widely expressed serine/threonine kinase, and its activation enhances cell proliferation. Here, we report that ATF1 is a novel substrate of RSK2 and that RSK2-ATF1 signaling plays an important role in EGF-induced neoplastic cell transformation. RSK2 phosphorylated ATF1 at Ser-63 and enhanc...

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Detalhes bibliográficos
Main Authors: Liu, Kangdong, Cho, Yong-Yeon, Yao, Ke, Nadas, Janos, Kim, Dong Joon, Cho, Eun-Jin, Lee, Mee-Hyun, Pugliese, Angelo, Zhang, Jishuai, Bode, Ann M., Dong, Ziming, Dong, Zigang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023503/
https://ncbi.nlm.nih.gov/pubmed/21098035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.147306
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