Histamine Regulates the Inflammatory Profile of SOD1-G93A Microglia and the Histaminergic System Is Dysregulated in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a late-onset motor neuron disease where activated glia release pro-inflammatory cytokines that trigger a vicious cycle of neurodegeneration in the absence of resolution of inflammation. Given the well-established role of histamine as a neuron-to-glia alarm sign...

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: Apolloni, Savina, Fabbrizio, Paola, Amadio, Susanna, Napoli, Giulia, Verdile, Veronica, Morello, Giovanna, Iemmolo, Rosario, Aronica, Eleonora, Cavallaro, Sebastiano, Volonté, Cinzia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714870/
https://ncbi.nlm.nih.gov/pubmed/29250069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01689
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