Two-cell embryos are more sensitive than blastocysts to AMPK-dependent suppression of anabolism and stemness by commonly used fertility drugs, a diet supplement, and stress

PURPOSE: This study tests whether metformin or diet supplement BR-DIM-induced AMP-activated protein kinase (AMPK) mediated effects on development are more pronounced in blastocysts or 2-cell mouse embryos. METHODS: Culture mouse zygotes to two-cell embryos and test effects after 0.5–1 h AMPK agonist...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Assist Reprod Genet
Egile Nagusiak: Bolnick, Alan, Abdulhasan, Mohammed, Kilburn, Brian, Xie, Yufen, Howard, Mindie, Andresen, Paul, Shamir, Alexandra M., Dai, Jing, Puscheck, Elizabeth E., Secor, Eric, Rappolee, Daniel A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Springer US 2017
Gaiak:
Embryo Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714821/
https://ncbi.nlm.nih.gov/pubmed/28913567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10815-017-1028-x
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