Commonly used fertility drugs, a diet supplement, and stress force AMPK-dependent block of stemness and development in cultured mammalian embryos

PURPOSE: The purpose of the present study is to test whether metformin, aspirin, or diet supplement (DS) BioResponse-3,3′-Diindolylmethane (BR-DIM) can induce AMP-activated protein kinase (AMPK)-dependent potency loss in cultured embryos and whether metformin (Met) + Aspirin (Asa) or BR-DIM causes a...

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Detalhes bibliográficos
Publicado no:J Assist Reprod Genet
Main Authors: Bolnick, Alan, Abdulhasan, Mohammed, Kilburn, Brian, Xie, Yufen, Howard, Mindie, Andresen, Paul, Shamir, Alexandra M, Dai, Jing, Puscheck, Elizabeth E, Rappolee, Daniel A
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2016
Assuntos:
Embryo Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974229/
https://ncbi.nlm.nih.gov/pubmed/27230877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10815-016-0735-z
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