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H(+) and Pi Byproducts of Glycosylation Affect Ca(2+) Homeostasis and Are Retrieved from the Golgi Complex by Homologs of TMEM165 and XPR1

Glycosylation reactions in the Golgi complex and the endoplasmic reticulum utilize nucleotide sugars as donors and produce inorganic phosphate (Pi) and acid (H(+)) as byproducts. Here we show that homologs of mammalian XPR1 and TMEM165 (termed Erd1 and Gdt1) recycle luminal Pi and exchange luminal H...

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Detalhes bibliográficos
Publicado no:G3 (Bethesda)
Main Authors: Snyder, Nathan A., Stefan, Christopher P., Soroudi, Camille T., Kim, Adam, Evangelista, Carlos, Cunningham, Kyle W.
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714488/
https://ncbi.nlm.nih.gov/pubmed/29042410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.117.300339
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