Polygenicity and Epistasis Underlie Fitness-Proximal Traits in the Caenorhabditis elegans Multiparental Experimental Evolution (CeMEE) Panel

Understanding the genetic basis of complex traits remains a major challenge in biology. Polygenicity, phenotypic plasticity, and epistasis contribute to phenotypic variance in ways that are rarely clear. This uncertainty can be problematic for estimating heritability, for predicting individual pheno...

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Bibliografiske detaljer
Udgivet i:Genetics
Main Authors: Noble, Luke M., Chelo, Ivo, Guzella, Thiago, Afonso, Bruno, Riccardi, David D., Ammerman, Patrick, Dayarian, Adel, Carvalho, Sara, Crist, Anna, Pino-Querido, Ania, Shraiman, Boris, Rockman, Matthew V., Teotónio, Henrique
Format: Artigo
Sprog:Inglês
Udgivet: Genetics Society of America 2017
Fag:
Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714472/
https://ncbi.nlm.nih.gov/pubmed/29066469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.117.300406
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