Polygenicity and Epistasis Underlie Fitness-Proximal Traits in the Caenorhabditis elegans Multiparental Experimental Evolution (CeMEE) Panel

Understanding the genetic basis of complex traits remains a major challenge in biology. Polygenicity, phenotypic plasticity, and epistasis contribute to phenotypic variance in ways that are rarely clear. This uncertainty can be problematic for estimating heritability, for predicting individual pheno...

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Detalhes bibliográficos
Publicado no:Genetics
Main Authors: Noble, Luke M., Chelo, Ivo, Guzella, Thiago, Afonso, Bruno, Riccardi, David D., Ammerman, Patrick, Dayarian, Adel, Carvalho, Sara, Crist, Anna, Pino-Querido, Ania, Shraiman, Boris, Rockman, Matthew V., Teotónio, Henrique
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2017
Assuntos:
Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714472/
https://ncbi.nlm.nih.gov/pubmed/29066469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.117.300406
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