Survival of BRCA2-Deficient Cells Is Promoted by GIPC3, a Novel Genetic Interactor of BRCA2

BRCA2 loss-of-heterozygosity (LOH) is frequently observed in BRCA2-mutated tumors, but its biallelic loss causes embryonic lethality in mice and inhibits proliferation of normal somatic cells. Therefore, it remains unclear how loss of BRCA2 contributes to tumorigenesis. One possibility is that mutat...

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Bibliografiske detaljer
Udgivet i:Genetics
Main Authors: Ding, Xia, Philip, Subha, Martin, Betty K., Pang, Yan, Burkett, Sandra, Swing, Deborah A., Pamala, Chinmayi, Ritt, Daniel A., Zhou, Ming, Morrison, Deborah K., Ji, Xinhua, Sharan, Shyam K.
Format: Artigo
Sprog:Inglês
Udgivet: Genetics Society of America 2017
Fag:
Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714451/
https://ncbi.nlm.nih.gov/pubmed/29021281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.117.300357
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