Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2

Human breast cancer susceptibility gene, BRCA2, encodes a 3418-amino acid protein that is essential for maintaining genomic integrity. Among the proteins that physically interact with BRCA2, Partner and Localizer of BRCA2 (PALB2), which binds to the N-terminal region of BRCA2, is vital for its funct...

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Vydáno v:PLoS Genet
Hlavní autoři: Hartford, Suzanne A., Chittela, Rajanikant, Ding, Xia, Vyas, Aradhana, Martin, Betty, Burkett, Sandra, Haines, Diana C., Southon, Eileen, Tessarollo, Lino, Sharan, Shyam K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973925/
https://ncbi.nlm.nih.gov/pubmed/27490902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006236
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